Vinh Q. Nguyen

vinh.nguyen@ucsf.edu

Publications:

Tax1bp1 enhances bacterial virulence and promotes inflammatory responses during Mycobacterium tuberculosis infection of alveolar macrophages.

Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains.

CRISPR screens decode cancer cell pathways that trigger γδ T cell detection.

Selective decrease of donor-reactive Tregs after liver transplantation limits Treg therapy for promoting allograft tolerance in humans.

Obesity alters pathology and treatment response in inflammatory disease.

CRISPR activation and interference screens decode stimulation responses in primary human T cells.

IL-6 and TNFa Drive Extensive Proliferation of Human Tregs Without Compromising Their Lineage Stability or Function.

Polyclonal Regulatory T Cell Manufacturing Under cGMP: A Decade of Experience.

The effects of low-dose IL-2 on Treg adoptive cell therapy in patients with Type 1 diabetes.

Precision Engineering of an Anti-HLA-A2 Chimeric Antigen Receptor in Regulatory T Cells for Transplant Immune Tolerance.

The SIRPα-CD47 immune checkpoint in NK cells.

Functional CRISPR dissection of gene networks controlling human regulatory T cell identity.

Landscape of stimulation-responsive chromatin across diverse human immune cells.

Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived ß cells.

Polyclonal Regulatory T Cell Therapy for Control of Inflammation in Kidney Transplants.

Mitigating Ischemic Injury of Stem Cell-Derived Insulin-Producing Cells after Transplant.

Cutting Edge: Origins, Recruitment, and Regulation of CD11c+ Cells in Inflamed Islets of Autoimmune Diabetes Mice.

Assessment of Immune Isolation of Allogeneic Mouse Pancreatic Progenitor Cells by a Macroencapsulation Device.

Type 1 diabetes immunotherapy using polyclonal regulatory T cells.

Therapeutic regulatory T cells subvert effector T cell function in inflamed islets to halt autoimmune diabetes.

Menin determines K-RAS proliferative outputs in endocrine cells.

Failure to achieve normal metabolic response in non-obese diabetic mice and streptozotocin-induced diabetic mice after transplantation of primary murine hepatocytes electroporated with the human proinsulin gene (p3MTChins).

An evolving autoimmune microenvironment regulates the quality of effector T cell restimulation and function.

Attenuation of donor-reactive T cells allows effective control of allograft rejection using regulatory T cell therapy.

IRE1a induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.